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Latest CAMEO Targets

2mwj, 2mwk, 3wr7, 4r5w, 4r62, 4r8d, 4rtc, 4rys, 4ryw, 4u72, 4u74, 4u7o, 4uhw, 4uhx, 4uil, 4uim, 4uin, 4uwb, 4uwc, 4uxb, 4whe, 4wlw, 4wp3, 4wp8, 4wp9, 4wpa, 4wq2, 4wq3, 4wu8, 4wu9, 4xtv, 4xtw, 4xtx, 4xty, 4xtz, 4xu0, 4xu1, 4xu2, 4xu3, 4xzz, 4y1s, 4y1t, 4y4v, 4y89, 4ybo, 4yi7, 4ynm, 4ynp, 4ynt, 4ynu, 4ypa, 4ype, 4ypu, 4z3m, 4z41, 4z7a, 4zfq, 4zgy, 4zk5, 4zkg, 4zl2, 4zl3, 4zo1, 4zs4, 4zs6, 4zst, 4zsu, 4ztl, 4ztm, 4ztn, 4zwe, 4zwg, 4zxa, 4zxc, 5a12, 5a13, 5a40, 5a41, 5a43, 5a55, 5a56, 5a57, 5a58, 5a59, 5a5a, 5a5w, 5a79, 5a7a, 5a8v, 5a96, 5a98, 5a99, 5a9a, 5a9p, 5aad, 5aae, 5aaf, 5aag, 5abi, 5abu, 5abx, 5aby, 5ahe, 5ahf, 5ajh, 5avq, 5avr, 5avs, 5avt, 5avu, 5avv, 5avw, 5avx, 5avy, 5avz, 5aw0, 5aw1, 5aw2, 5aw3, 5aw4, 5aw5, 5aw6, 5aw7, 5aw8, 5aw9, 5axw, 5box, 5bp5, 5bpd, 5bpi, 5bpz, 5bq5, 5bqt, 5brr, 5bvp, 5byh, 5c0r, 5c8j, 5cb8, 5cc8, 5ccu, 5cd7, 5cd8, 5cd9, 5cjh, 5cxl, 5czz, 5d10, 5d5g, 5d66, 5d67, 5d69, 5d9h, 5d9k, 5d9l, 5d9u, 5dau, 5deh, 2ms7, 2ms8, 2n35, 2n5t, 3j9j, 4qpr, 4tz7, 4u7n, 4uik, 4wls, 4xei, 4xz8, 4xza, 4xzc, 4xze, 4zgz, 4zm7, 4zxd, 5a8s, 5a8t, 5a8u, 5a9b, 5a9c, 5a9v, 5abv, 5bpt, 5bpw, 5bvj, 5bxb, 5bxd, 5bxh, 5c0s
CAMEO Structure Annotation is an editable collection of target protein structures within the "Continuous Automated Model EvaluatiOn" (CAMEO).

Here we welcome any scientist/user to join in and annotate the ligands of the CAMEO Structures. The more precise the ligands are annotated the better the automated evaluation can be performed. In this way the method developers directly benefit from your knowledge gained in many experiments/studies and in turn your input results in better models for your predictions.

Your feedback in general is, hence, very welcome and appreciated!

Annotating is straightforward and more fun if the load can be spread, so please spread the word - and - annotate!
New CAMEO Targets this week (2015-08-29):
A YidC-like protein in the archaeal plasma membrane5c8j
ASH1L SET domain H2193F mutant in complex with S-adenosyl methionine (SAM)4ype
ASH1L SET domain K2264L mutant in complex with S-adenosyl methionine (SAM)4ypu
ASH1L SET domain Q2265A mutant in complex with S-adenosyl methionine (SAM)4ypa
ASH1L SET domain S2259M mutant in complex with S-adenosyl methionine (SAM)4ynp
ASH1L wild-type SET domain in complex with S-adenosyl methionine (SAM)4ynm
Active histidine kinase bound with ATP4u7o
Anthranilate bound at active site of anthranilate phosphoribosyl transferase from Acinetobacter (AnPRT; TrpD)4yi7
Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain5bpz, 5bpt, 5bpw
Aurora A kinase bound to an imidazopyridine inhibitor (14a)5aaf
Aurora A kinase bound to an imidazopyridine inhibitor (14b)5aag
Aurora A kinase bound to an imidazopyridine inhibitor (14d)5aae
Aurora A kinase bound to an imidazopyridine inhibitor (7a)5aad
CRYSTAL STRUCTURE OF GAF DOMAIN of POTASSIUM SENSOR HISTIDINE KINASE KDPD FROM ESCHERICHIA COLI4qpr
CRYSTAL STRUCTURE OF RTX DOMAIN BLOCK V OF ADENYLATE CYCLASE TOXIN FROM BORDETELLA PERTUSSIS5cxl
CRYSTAL STRUCTURE OF THE AG(I) (ACTIVATOR) FORM OF E. COLI CUER, A COPPER EFFLUX REGULATOR, BOUND TO COPA PROMOTER DNA4wlw
Complex of C. elegans eIF4E-3 with the 4E-binding protein Mextli5aby
Complex of C. elegans eIF4E-3 with the 4E-binding protein Mextli and cap analog5abx
Complex of D. melanogaster eIF4E with the 4E-binding protein Mextli5abv
Complex of D. melanogaster eIF4E with the 4E-binding protein Mextli and cap analog5abu
Crystal Structure of Adenylyl cyclase from Mycobacterium avium Ma1120 wild type4wp3
Crystal Structure of Escherichia coli RNA polymerase - Sigma54 Holoenzyme complex5byh
Crystal Structure of Eukaryotic Oxoiron (IV) MagKatG2 at pH 8.55cjh
Crystal Structure of SMAD5-MH1 in complex with a composite DNA sequence4zl3
Crystal Structure of SMAD5-MH1/GC-BRE DNA complex4zl2
Crystal Structure of SMAD5-MH1/palindromic SBE DNA complex4zkg
Crystal Structure of Spermidine Acetyltransferase from Escherichia coli3wr7
Crystal Structure of a Generation 3 Influenza Hemagglutinin Stabilized Stem Complexed with the Broadly Neutralizing Antibody C1795c0r
Crystal Structure of a kinase4tz7
Crystal Structure of hydroquinone 1,2-dioxygenase PnpCD4zxd
Crystal Structure of hydroquinone 1,2-dioxygenase PnpCD in complex with Cd2+ and 4-hydroxybenzonitrile4zxa
Crystal Structure of hydroquinone 1,2-dioxygenase PnpCD in complex with Fe3+4zxc
Crystal Structure of the Inactive Alpha-kinase Domain of Myosin-II Heavy Chain Kinase A (D756A) Complexed with ATP4zs4
Crystal Structure of the T3-bound TR-beta Ligand-binding Domain in complex with RXR-alpha4zo1
Crystal structure of 4-phenylimidazole bound form of human indoleamine 2,3-dioxygenase (A260G mutant)4u72
Crystal structure of 4-phenylimidazole bound form of human indoleamine 2,3-dioxygenase (G262A mutant)4u74
Crystal structure of Adenosine-5'-phosphosulfate kinase in complex with APS and sulfate5cb8
Crystal structure of Adenylyl cyclase MA1120 from Mycobacterium Avium bound to 2'5'-DD-3'-ATP, Calcium and Magnesium ion4wp9
Crystal structure of Adenylyl cyclase Ma1120 from Mycobacterium Avium bound to Pyrophosphate and Calcium4wpa
Crystal structure of Adenylyl cyclase Ma1120 from Mycobacterium Avium in complex with 2'5'-DD-3'-ATP and Manganese ion4wp8
Crystal structure of Antheraea mylitta CPV4 polyhedra base domain deleted mutant5a9c
Crystal structure of Antheraea mylitta CPV4 polyhedra type 15a8s
Crystal structure of Antheraea mylitta CPV4 polyhedra type 25a8t
Crystal structure of Aspergillus flavus FAD glucose dehydrogenase4ynt
Crystal structure of Aspergillus flavus FADGDH in complex with D-glucono-1,5-lactone4ynu
Crystal structure of Bombyx mori CPV1 polyhedra base domain deleted mutant5a9b
Crystal structure of Brevundimonas diminuta phosphotriesterase mutant L7eP-3a4zst
Crystal structure of Brevundimonas diminuta phosphotriesterase mutant L7eP-3aG4zsu
Crystal structure of Chlorite Dismutase from Magnetospirillum sp. in complex with azide5a12
Crystal structure of Chlorite Dismutase from Magnetospirillum sp. in complex with thiocyanate5a13
Crystal structure of E. coli phage shock protein A (PspA 1-144)4whe
Crystal structure of Fusarium oxysporum cutinase5ajh
Crystal structure of HA17-HA33-IPT5bp5
Crystal structure of Lymantria dispar CPV14 polyhedra5a96
Crystal structure of Operophtera brumata CPV18 polyhedra5a9p
Crystal structure of Operophtera brumata CPV19 polyhedra5a99
Crystal structure of Orgyia pseudotsugata CPV5 polyhedra5a8u
Crystal structure of Orgyia pseudotsugata CPV5 polyhedra with SeMet substitution5a8v
Crystal structure of Rv1600 encoded aminotransferase in complex with PLP-MES from Mycobacterium tuberculosis4r8d
Crystal structure of SPAK (STK39) dimer in the basal activity state5d9h
Crystal structure of Salmonella enterica HisA5ahe
Crystal structure of Salmonella enterica HisA D7N D176A with ProFAR5a5w
Crystal structure of Salmonella enterica HisA D7N with ProFAR5ahf
Crystal structure of Simulium ubiquitum CPV20 polyhedra5a9a
Crystal structure of Staphylococcal nuclease variant Delta+PHS N100D at cryogenic temperature5deh
Crystal structure of Staphylococcal nuclease variant Delta+PHS V39E/V104E at cryogenic temperature5dau
Crystal structure of Staphylococcus aureus Cas9 in complex with sgRNA and target DNA (TTGAAT PAM)5czz
Crystal structure of Staphylococcus aureus Cas9 in complex with sgRNA and target DNA (TTGGGT PAM)5axw
Crystal structure of Trichoplusia ni CPV15 polyhedra5a98
Crystal structure of a dual topology fluoride ion channel5a41
Crystal structure of a dual topology fluoride ion channel.5a40, 5a43
Crystal structure of a generation 4 influenza hemagglutinin stabilized stem in complex with the broadly neutralizing antibody CR62615c0s
Crystal structure of an EF-Hand calcium binding domain of CAP-Binding Protein Complex-Interacting Protein 1 (EFCAB6) from Homo sapiens at 2.00 A resolution5d67
Crystal structure of an ankyrin repeat domain (ABAYE2397) from Acinetobacter baumannii AYE at 1.00 A resolution5d66
Crystal structure of endoglycoceramidase I from Rhodococ-cus equi5ccu
Crystal structure of pentameric KCTD1 BTB domain form 15bxb
Crystal structure of pentameric KCTD1 BTB domain form 25bxd
Crystal structure of pentameric KCTD9 BTB domain5bxh
Crystal structure of the CTD of Drosophila Oskar protein5cd9
Crystal structure of the IstB AAA+ domain bound to ADP-BeF35bq5
Crystal structure of the N-terminal domain of CEACAM74y89
Crystal structure of the NTD L199M of Drosophila Oskar protein5cd7
Crystal structure of the NTD of Drosophila Oskar protein5cd8
Crystal structure of the dGTP-bound catalytic core of SAMHD1 T592V mutant4zwe
Crystal structure of the dGTP-bound catalytic core of SAMHD1 phosphomimetic T592E mutant4zwg
Crystal structure of the green fluorescent rotein NowGFP (the variant of cyan Cerulean) at pH 4.84rys
Crystal structure of the green fluorescent variant, nowGFP, of the cyan Cerulean at pH 9.04rtc
Crystal structure of the metal-free (repressor) form of E. Coli CUER, a copper efflux regulator, bound to COPA promoter DNA4wls
Crystal structure of the photoconverted green fluorescent protein NowGFP_conv (the variant of cyan Cerulean) at pH 7.04ryw
Ensemble Solution structure of the phosphoenolpyruvate-Enzyme I complex from the bacterial hosphotransferase system2n5t
Family 1 Carbohydrate-Binding Module from Trichoderma reesei Cel7A with O-mannose residues at Thr1, Ser3, and Ser142mwk
Fibroblast growth factor receptor 1 kinase in complex with JK-P34uwc
Fibroblast growth factor receptor 1 kinase in complex with JK-P54uwb
Fusion to a Highly Stable Consensus Albumin Binding Domain Allows for Tunable Pharmacokinetics2n35
High-resolution solid-state NMR structure of the helical signal transduction filament MAVS CARD2ms7
Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor PJ344uxb
Human aldehyde oxidase4uhw
Human aldehyde oxidase in complex with phthalazine and thioridazine4uhx
Human artd1 (parp1) - catalytic domain in complex with inhibitor xav9394r5w
Human calpain PEF(S) with (2Z,2Z')-2,2'-disulfanediylbis(3-(6-bromoindol-3-yl)acrylic acid) bound4wq3
Human calpain PEF(S) with (2Z,2Z')-2,2'-disulfanediylbis(3-(6-iodoindol-3-yl)acrylic acid) bound5d69
Human calpain PEF(S) with (Z)-3-(6-bromondol-3-yl)-2-mercaptoacrylic acid bound4wq2
Identification of a Water-Bridge Mediated Recognition Module at the mRNA Cap-Binding Interface of eIF4E5abi
Inactive structure of histidine kinase4u7n
Irak4-inhibitor co-structure4ztl, 4ztm, 4ztn
Kinase domain of cSrc in complex with RL2365d10
Kinetics by X-ray crystallography: E2.MgF42-.2RB+ crystal5aw8
Kinetics by X-ray crystallography: Rb+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 1.5 min5aw4
Kinetics by X-ray crystallography: Rb+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 11.3 min5aw7
Kinetics by X-ray crystallography: Rb+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 2.2 min5aw5
Kinetics by X-ray crystallography: Rb+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 5.5 min5aw6
Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 0.75 min.5avq
Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 1.5 min5avr
Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 100 min5aw3
Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 16.5 min5avw
Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 20 min5avx, 5avy
Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 3.5 min5avs
Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 5 min5avt
Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 55 min5avz, 5aw0
Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 7.0 min5avu
Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 8.5 min5avv
Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 85 min5aw1, 5aw2
Kinetics by X-ray crystallography: native E2.MgF42-.2K+ crystal for Rb+ bound crystals5aw9
MAP4K4 in complex with inhibitor GNE-4954zk5
Michaelis complex of tPA-S195A:PAI-15brr
Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 36 (N-({[(1R,3S)-3-(6-amino-9H-purin-9-yl)cyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide)4xtv
Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 46 with azide in place of 2'OH4xtw
Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 57 with azide in place of ribose 2'OH4xtx
Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 63 with Fluorine in place of 2'OH4xty
Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 69 that has a fluorine in place of the ribose 2'OH4xtz
Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 73 that has a 2'-methyl on the ribose4xu0
Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 82 that incorporates a morpholine in place of the ribose4xu1
Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 87 with a 3'deoxy ribose4xu2
Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 90 that has an acyclic ether in place of the ribose4xu3
Novel inter-subunit contacts in Barley Stripe Mosaic Virus revealed by cryo-EM5a79, 5a7a
Orthorhombic isomorph of bovine Arp2/3 complex4xei
PcCel45A N105D mutatnt at cryo condition4zm7
Receptor binding domain and Fab complex4zs6
Rsk2 N-terminal Kinase in Complex with BI-D18705d9k
Rsk2 N-terminal Kinase in Complex with bis-phenol pyrazole5d9l
STRUCTURE OF HUMAN ANTIZYME INHIBITOR IN COMPLEX WITH A C-TERMINAL FRAGMENT OF ANTIZYME4zgz
STRUCTURE of HUMAN ORNITHINE DECARBOXYLASE IN COMPLEX WITH A C-TERMINAL FRAGMENT OF ANTIZYME4zgy
Solution NMR structure of MAVS CARD2ms8
Solution structure of Family 1 Carbohydrate-Binding Module from Trichoderma reesei Cel7A with O-mannose residues at Thr1 and Ser32mwj
Structural and biochemical characterization of a non-functionally redundant M. tuberculosis (3,3) L,D-Transpeptidase, LdtMt5.4z7a
Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes4y1s, 4y1t
Structure of Citrate Synthase from the Thermoacidophilic Euryarchaeon Thermolasma acidophilum4ybo
Structure of Helicobacter pylori Csd6 in the D-Ala-bound state4y4v
Structure of Helicobacter pylori Csd6 in the ligand-free state4xzz
Structure of M. tuberculosis (3,3) L,D-Transpeptidase, LdtMt5. (Meropenen-adduct form)4zfq
Structure of Rad6~Ub4r62
Structure of TrmBL2, an archaeal chromatin protein, shows a novel mode of DNA binding.5box, 5bpd, 5bpi, 5bqt
Structure of apo BipA5a9v
Structure of cisPtNAP-NCP1454wu9
Structure of colocasia esculenta agglutinin5d5g
Structure of the capsaicin receptor, TRPV1, determined by single particle electron cryo-microscopy3j9j
Structure of thiamine-monophosphate kinase from Acinetobacter baumannii in complex with AMPPNP5cc8
Structure of thiamine-monophosphate kinase from Acinetobacter baumannii in complex with adenosine diphosphate (ADP) and thiamine diphosphate (TPP), orthorhombic crystal form5d9u
Structure of trPtNAP-NCP1454wu8
The crystal structure of Erve virus nucleoprotein4xz8, 4xza
The crystal structure of Hazara virus nucleoprotein4xze
The crystal structure of Kupe virus nucleoprotein4xzc
The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta5bvp, 5bvj
The native structure of GH101 from Streptococcus pneumoniae TIGR45a55
The structure of GH101 D764N mutant from Streptococcus pneumoniae TIGR4 in complex with serinyl T-antigen5a58
The structure of GH101 E796Q mutant from Streptococcus pneumoniae TIGR4 in complex with PNP-T-antigen5a5a
The structure of GH101 E796Q mutant from Streptococcus pneumoniae TIGR4 in complex with T-antigen5a59
The structure of GH101 from Streptococcus pneumoniae TIGR4 in complex with 1-O-methyl-T-antigen5a56
The structure of GH101 from Streptococcus pneumoniae TIGR4 in complex with PUGT5a57
X-ray structure of the adduct formed in the reaction between lysozyme and a platinum(II) Complex with S,O Bidentate Ligands (9b)4z3m
X-ray structure of the adduct formed in the reaction between lysozyme and a platinum(II) Compound with a S,O Bidentate Ligand (9a=Chloro-(1-(3'-hydroxy)-3-(methylthio)-3-thioxo-prop-1-en-1-olate-O,S)-(dimethylsulfoxide-S)-platinum(II))4z41
crystal structure of quinine-dependent Fab 314.14uik
crystal structure of quinine-dependent Fab 314.1 with quinine4uil
crystal structure of quinine-dependent Fab 314.34uim
crystal structure of quinine-dependent Fab 314.3 with quinine4uin
CAMEO Targets still open for annotating:
CAMEO Targets now closed for annotation: