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Latest CAMEO Targets

3zmh, 3zmi, 3zmj, 4att, 4bfq, 4bhz, 4bi0, 4bi1, 4bi2, 4ef3, 4f7r, 4f8z, 4geo, 4gg1, 4gpi, 4hsa, 4i5c, 4inc, 4ini, 4jai, 4jaj, 4jpg, 4jv3, 4jxi, 4k6c, 4k8d, 4k8g, 4k93, 4k9c, 4k9i, 4ka0, 4kad, 4kah, 4kal, 4kan, 4kbe, 4kcf, 4kds, 4kf9, 4kfr, 4kfs, 4kft, 4kfu, 4kjh, 4kjx, 4kkr, 4kl4, 4klk, 4klv, 4klw, 4kmk, 4kmu, 4kn4, 4kn7, 4knz, 4kpk, 2lra, 2lrb, 2m75, 2m7f, 2m7h, 4bmf, 4eyy, 4fjw, 4hl6, 4hr9, 4j8r, 4jgf, 4kkp, 4kkq, 4kms, 4knd, 4knp, 4kpg
CAMEO Structure Annotation is an editable collection of target protein structures within the "Continuous Automated Model EvaluatiOn" (CAMEO).

Here we welcome any scientist/user to join in and annotate the ligands of the CAMEO Structures. The more precise the ligands are annotated the better the automated evaluation can be performed. In this way the method developers directly benefit from your knowledge gained in many experiments/studies and in turn your input results in better models for your predictions.

Your feedback in general is, hence, very welcome and appreciated!

Annotating is straightforward and more fun if the load can be spread, so please spread the word - and - annotate!
New CAMEO Targets this week (17-05-2013):
2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as Novel PKM2 Activators4jpg
Assembly of a triple pi-stack of ligands in the binding site of Aplysia californica acetylcholine binding protein (AChBP)4bfq
CRYSTAL STRUCTURE OF probable sugar kinase protein from Rhizobium etli CFN 42 complexed with N-(HYDROXYMETHYL)BENZAMIDE4k93
CRYSTAL STRUCTURE OF probable sugar kinase protein from Rhizobium etli CFN 42 complexed with N-(HYDROXYMETHYL)BENZAMIDE and 4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBOXYLIC ACID4k9c
CRYSTAL STRUCTURE OF probable sugar kinase protein from Rhizobium etli CFN 42 complexed with Norharmane4k9i
Carboxypeptidase T with Boc-Leu4f8z
Crystal Structure Of a Putative enoyl-coA hydratase (PSI-NYSGRC-019597) from Mycobacterium avium paratuberculosis K-104knp
Crystal Structure of Aurora Kinase A in complex with BENZO[C][1,8]NAPHTHYRIDIN-6(5H)-ONE4jaj
Crystal Structure of Aurora Kinase A in complex with N-{4-[(6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridin-1-yl)amino]phenyl}benzamide4jai
Crystal Structure of Benzoylformate Decarboxylase Mutant L403T4gg1
Crystal Structure of the Cataract-Causing P23T gamma D-Crystallin Mutant4jgf
Crystal Structure of the IcmR-IcmQ complex from Legionella pneumophila4eyy
Crystal Structure of the apo form of the E131Q Mtb crotonase4fjw
Crystal Structure of the complex of three phase partition treated lipase from Thermomyces lanuginosa with Lauric acid and P-nitrobenzaldehyde (PNB) at 2.1 resolution4kjx
Crystal structure of 14-3-3 protein from Giardia intestinalis4f7r
Crystal structure of Acetoacetyl-CoA reductase from Rickettsia felis4kms
Crystal structure of D-Mannonate dehydratase from Novosphingobium aromaticivorans mutant (V161A, R163A, K165G, L166A, Y167G, Y168A, E169G)4k8g
Crystal structure of MycP1 from the ESX-1 type VII secretion system4kpg
Crystal structure of Ribosome Inactivating protein from Momordica balsamina at 1.65 A resolution4kmk
Crystal structure of Ribosome inactivating protein from Momordica balsamina complexed with Polyethylene glycol at 1.90 Angstrom resolution4kl4
Crystal structure of Vibrio cholerae RbmA (crystal form 1)4kkq
Crystal structure of Vibrio cholerae RbmA (crystal form 2)4kkp
Crystal structure of Vibrio cholerae RbmA (crystal form 3)4kkr
Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with 2-(aminocarbonyl)benzoate4klw
Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with 4-methylumbelliferyl phosphate4klv
Crystal structure of a enoyl-CoA hydratase from Shewanella pealeana ATCC 7003454kpk
Crystal structure of a glutathione transferase family member from ralstonia solanacearum, target efi-501780, with bound gsh coordinated to a zinc ion, ordered active site4kf9
Crystal structure of a putative thiol-disulfide oxidoreductase from Bacteroides vulgatus (target NYSGRC-011676), space group P212214ka0
Crystal structure of beta-ketoacyl synthase from Brucella melitensis in complex with platencin<structure_details =4jv3
Crystal structure of human B type phosphoglycerate mutase4gpi
Crystal structure of latent rainbow trout plasminogen activator inhibitor 1 (PAI-1)4kds
Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with 2-(2,5-dimethyl-1,3-thiazol-4-yl)acetic acid4kan
Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with 4-bromo-1H-pyrazole4kah
Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with N1-(2.3-dihydro-1H-inden-5-yl)acetam4kad
Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with benzoguanamine4kbe
Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with quinoline-3-carboxylic acid4kal
Crystal structure of the C558(464)A/C559(465)A double mutant of Tn501 MerA in complex with NADPH and Hg2+4k8d
Crystal structure of the complex of ribosome inactivating protein from Momordica balsamina with cytosine at 1.98 A resolution4kjh
Directed evolution and rational design of a de novo designed esterase toward improved catalysis. Northeast Structural Genomics Consortium (NESG) Target OR1844jxi
FimH lectin domain co-crystal with a alpha-D-mannoside O-linked to a propynyl para methoxy phenyl4att
Human Histidine Triad Nucleotide Binding Protein 24inc
Human Histidine Triad Nucleotide Binding Protein 2 with Bound AMP4ini
Human interleukin 17A4hr9
Multicopper Oxidase CueO (Citrate buffer)4ef3
NMR Structure of Signal Sequence Deleted (SSD) Rv0603 Protein from Mycobacterium tuberculosis without N-terminal His-tag2lra
P38a MAP kinase DEF-pocket penta mutant (M194A, L195A, H228A, I229A, Y258A)4geo
Phage-related protein DUF2815 from Enterococcus faecalis4klk
Scaffold Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitor4bhz, 4bi0, 4bi1, 4bi2
Solution Structure of ADF like UNC-60A Protein of Caenorhabditis elegans2lrb
Solution structure of the cellulose-binding domain of endoglucanase I from Trichoderma reesei and its interaction with cello- oligosaccharides4bmf
Structure of E.coli rhomboid protease GlpG in complex with monobactam L293zmi
Structure of E.coli rhomboid protease GlpG in complex with monobactam L613zmj
Structure of E.coli rhomboid protease GlpG in complex with monobactam L623zmh
Structure of an octapeptide repeat of the prion protein bound to the POM2 Fab antibody fragment4j8r
Structure of interleukin 17a in complex with il17ra receptor4hsa
Structure of the genome packaging NTPase B204 from Sulfolobus turreted icosahedral virus 2 in complex with AMP4kfs
Structure of the genome packaging NTPase B204 from Sulfolobus turreted icosahedral virus 2 in complex with AMPPCP4kfu
Structure of the genome packaging NTPase B204 from Sulfolobus turreted icosahedral virus 2 in complex with ATP-gammaS4kft
Structure of the genome packaging NTPase B204 from Sulfolobus turreted icosahedral virus 2 in complex with sulfate4kfr
The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Integrin alpha-IIb beta-3 Recognition2m7h
The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Integrins Recognitions2m7f
The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Recognitions of Integrins2m75
The Jak1 kinase domain in complex with inhibitor4i5c
Thioredoxin from Anaeromyxobacter dehalogenans.4knd
Thymidylate synthase ternary complex with dUMP AND CB37174knz
X-ray Structure of a KijD3 in Complex with FMN and dTDP-3-amino-2,3,6-trideoxy-4-keto-3-methyl-D-glucose4kcf
X-ray crystal structure of a putative Acetoacyl-CoA reductase from Burkholderia cenocepacia4k6c
X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2b4kn4
X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2c4kn7
X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Rifampin4kmu
YfdE from Escherichia coli4hl6
CAMEO Targets still open for annotating:
CAMEO Targets now closed for annotation: